Debra Lynn Messing born August 15, 1968 is an American actress, best known for her role as Grace Adler in the sitcom Will & Grace. Messing was born in the Brooklyn borough of New York City, the daughter of Sandra (n'e Simons), who has worked as a professional singer, banker, travel and real estate agent, and Brian Messing, a sales executive for a costume jewelry packaging manufacturer. Messing is Jewish, a descendant of immigrants from Russia and Poland. When Messing was three, she moved with her parents and her older brother, Brett, to East Greenwich, a small town outside Providence, Rhode Island. During her high school years, she acted and sang in a number of high school productions at East Greenwich High School, including the starring roles in the musicals Annie and Grease. She took lessons in dance, singing, and acting. In 1986, she was Rhode Island's Junior Miss and competed in Mobile, Alabama in the America's Junior Miss scholarship program. While her parents encouraged her dream of becoming an actress, they also urged her to complete a liberal arts education before deciding on acting as a career. Following their advice, she attended Brandeis University in Waltham, Massachusetts.

During her junior year, she studied theater at the prestigious London-based British European Studio Group program, an experience that solidified her desire to act. Some time after 1986 she underwent surgical rhinoplasty. In 1990, after graduating summa cum laude from Brandeis University with a bachelor's degree in theater arts, Messing gained admission to the elite Graduate Acting Program at New York University's Tisch School of the Arts which accepts approximately fifteen new students annually. She earned a Master's Degree in Fine Arts after three years. In 1993, Messing won praise for her acting in the pre-Broadway workshop production of Tony Kushner's play Angels in America: Perestroika. Subsequently, she appeared in several episodes of the television series NYPD Blue during 1994 and 1995. Messing at the premiere of Woody Allen's Whatever Works.

In 1995, Messing made her film debut in Alfonso Arau's A Walk in the Clouds playing the unfaithful wife of main character Paul Sutton (Keanu Reeves). This exposure led the Fox network to make her the co-star of the television sitcom, Ned & Stacey. The series lasted for two seasons, from 1995 to 1997. Messing appeared as Jerry Seinfeld's date in two episodes of the series Seinfeld: "The Wait Out" in 1996 and "The Yada Yada" in 1997. Messing turned down a starring role in another television sitcom to appear in Donald Margulies's two-character play Collected Stories, which opened at the Off-Broadway Manhattan Theater Club.

She also co-starred in the Tom Arnold vehicle McHale's Navy in 1997. In 1998, Messing played a lead role as the bio-anthropologist Sloan Parker on ABC's dramatic science fiction television series Prey. During this time her agent approached her with the pilot script for the television show Will & Grace. Messing was inclined to take some time off, but the script intrigued her, and she auditioned for the role of Grace Adler, beating out Nicollette Sheridan, who later guest-starred on the show as a romantic rival of Grace's. Will & Grace became a ratings success, and Messing became a star. In 2002, she was named one of the "50 Most Beautiful People in the World" by People Magazine. TV Guide picked her as its "Best Dressed Woman" in 2003. Messing was cast by director Woody Allen in a small role in his 2002 film Hollywood Ending. Her film roles since include a happily married but ill-fated wife in the supernatural thriller The Mothman Prophecies (2002) and a supporting role in Along Came Polly (2004). The Wedding Date (2005) was Messing's first leading role in a high-profile film. It received mixed reviews but performed fairly well at the box office. Messing was featured as a judge on the season finale of the second season of Bravo's reality show, Project Runway. She also starred in the television mini-series The Starter Wife, which was nominated for ten Emmy awards including one for Messing for Outstanding Lead Actress in a Miniseries or Movie. In 2008, Messing reprised her role as Molly Kagan in the television series The Starter Wife, which included 10 episodes. In early 2010, Messing will star in the new ABC comedy series Wright vs. Wrong for the 2010-2011 primetime season.

Messing met her husband, Daniel Zelman, an actor and screenwriter, on their first day as graduate students at NYU in 1990. They were married on September 3, 2000, and live in New York City. On April 7, 2004, Messing gave birth to their son, Roman Walker Zelman. Its said that while filming her sitcom Will and Grace she told friends that givin a real situation were a man was gay that she could in fact turn him straight. One of her close friends she knew had a gay friend so they put her to the test by invited the two of them out. Deborah didnt make any moves the first couple of times they all went out in a group but by the third night they went out it was on. They were all sitting around having a few drinks and she brought up sexuality. Showing this gay guy all the attention she sat a little closer to him telling him that she could give him a night that no man ever could. Denying that she had any chance the guy allowed her to continue to try and convince him and even allowed her to rub against him. Deborah pushed the envelope by rubbing his crotch on the outside of his pants. Though the guy tried to deny it that proof was clear as he started to get hard and it was very clear he was actually enjoying it. She continued to do this while nibbling on his ear she finally got him to say "well i am gay and love guys buy i am so turned on right now i would fuck you".